In Chapter I, an 'Old townswoman' will tell Geralt about werewolves in exchange for food.

In the Prologue, Lambert claims silver is best to use against werewolves, but the conversation does not result in a bestiary entry.Danielle Stone, The Curse of Baron Wolfstein and Other Love Stories Location 'What about our love?' In reply she heard a terrifying roar. The baron's body swelled as his muscles grew, his noble attire fell in tatters on the marble floor. Suddenly the scent of his wife's blood and the blood of his children intensified. Journal Bestiary Entry Baron Wolfstein buried his face in his hands. It is up to our hero to determine the werewolf's true identity. In the game, the werewolf is not only a boss monster, but also the subject of a quest. Lycanthropes are usually on good terms with other canines, but hate werecats. Werewolves have a legendary sense of smell, exceptional even amongst real wolves. According to Herbolth, lands in the Toina valley, also called the Dogbane, were plagued by werewolves before the Nordling colonization. Therianthropy diseases, including lycanthropy, appeared in the world after the Conjunction of the Spheres, affecting nonhuman and early human populations alike. The wolfsbane is said to mitigate the illness' symptoms.

Those who became werewolves during their lives however are the only ones who can be cured.

Those who are born as werewolves are able to fully control their shapeshifting abilities, while those cursed or bitten change into their werewolf form only during the full moon. Being bitten by another werewolf, while popular in folk tales, gives only a very small chance of becoming one in reality, though it is still recommended to get magical treatment. There are two most common ways to aquire lycanthropy: the first one through a curse and the second is to simply have a werewolf parent. As other such creatures, they are hardly hurt by steel but very vulnerable to silver. Werewolves are therianthropes who transform into wolves or half-wolves.

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